Novel brain map tracks early brain atrophy from HIV infection

A new map of brain tissue in people with HIV shows atrophy in several areas including a primary neurocognitive control center where shrinkage and loss of function can be seen in scans before clinical symptoms appear.

The brain map paints a two-stage model of what exposure to HIV does to the brain, says the senior author, Xiong Jiang, PhD, director of the Cognitive Neuroimaging Laboratory at Georgetown.

"The drugs we use to keep HIV at bay work wonderfully well in the body, but they cannot easily reach the brain due to the blood-brain barrier," says Jiang. "We have long known about neurocognitive impairment resulting from HIV, but this is the first time we have a neural model to relate neurocognitive impairment severity to injury in certain brain structures." HIV-associated neurocognitive disorders are known as HAND.

The model shows the sweep of atrophy that occurs as time passes from initial viral infection. It suggests that early on in HIV+ disease, the virus affects the frontal lobe, considered to be the essential hub of brain networks, responsible for such high-level tasks as attention and executive and cognitive functioning. By contrast, the injury to the caudate/striatum area, a subcortical region and part of the motor and reward system, becomes more prominent when individuals develop clinical HAND symptoms.

"There is a strong desire for a neural model of HAND severity, which currently is solely defined by neurobehavioral assessments using standard neuropsychological tests," he says. "This model, while highly simplified, might have the potential to help to develop targeted treatment, which in turn might be more effective."

The researchers found that the frontal region (including anterior cingulate cortex, or ACC) is the most frequently affected brain region in HIV+ adults, whereas the neural injury to the caudate/striatum was consistently linked to neurocognitive impairment.

These results suggest a two-stage model of HAND in the context of brain atrophy, with a frontal/ACC stage that links to HIV disease and likely other comorbidities, such as substance abuse, and a caudate/striatum stage that links to neurocognitive impairment. "These two areas likely play different roles in HAND," Jiang says.

"It is our theory, and others, that the frontal/ACC area damage is due to a number of factors, but which importantly includes damage to the dopaminergic region," he says. "Also, we believe the caudate might be one of the key HIV reservoirs in the brain.

https://www.sciencedaily.com/releases/2019/03/190328150915.htm#

Source: Georgetown University Medical Center

After the magnificent success of World Congress on HIV AIDS STD and STI which was held in Valencia, Spain during April 23-25, 2018, we are proudly announcing the 2nd World Congress on HIV AIDS STD and STI during September 09-10, 2019 at Bangkok, Thailand.

HIV AIDS Congress 2019 is the best platform for interdisciplinary researchers, practitioners, academics, research scientists, students and healthcare industrialists to meet, share, discuss and exchange the most recent relevant experiences in their practices. This would centre on presentations and discussions on research oriented results on all aspects of HIV and AIDS. Consequently, it will provide the necessary platform to both transfer and exchange relevant knowledge in the field of HIV and AIDS.

www.hiv-aidsconference.org